Relationship Between Blood Lead Levels and Hematological Indices in Pregnant Women
DOI: 10.1080/03630242.2014.972019
Title: Relationship Between Blood Lead Levels and Hematological Indices in Pregnant Women
Journal Title: Women & Health
Volume: Volume 55
Issue: Issue 1
Publication Date: January 2015
Start Page: 90
End Page: 102
Published online: 22 Dec 2014
ISSN: 0363-0242
Author: Osmel La-Llave-León PhDa*, Rodrigo Lugo-Soto MDb, Marisela Aguilar-Durán PhDa, Sergio Estrada-Martínez MDa, José-Manuel Salas-Pacheco PhDa, Ada Sandoval-Carrillo MDa, Francisco Xavier Castellanos-Juárez PhDa, Marcel Barraza-Salas PhDa, Fernando Vázquez-Alanís PhDc & Gonzalo García-Vargas PhDd
Affiliations:
a Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, Durango, México
b Hospital de El Salto, Secretaría de Salud de Durango, Durango, Durango, México
c Hospital General de Durango, Secretaría de Salud de Durango, Durango, Durango, México
d Facultad de Medicina de Gómez Palacio, Universidad Juárez del Estado de Durango, Gómez Palacio, Durango, México
Abstract: Several studies have revealed a negative association between blood lead levels and hematological impairment. In this cross-sectional study, we examined the Relationship between blood lead levels and hematological indices in 292 pregnant women from Durango, Mexico. Apparently healthy pregnant women, aged 14–41 years and at 3–41 weeks of gestation, were recruited between June 2007 and May 2008. Blood lead and hematological indices were measured. The mean blood lead was 2.79 ± 2.16 μg/dL, and lead levels ≥5 μg/dL were detected in 25 women (8.6%). Hemoglobin, hematocrit, and red blood cells count were significantly higher in pregnant women with a blood lead concentration of ≥5 μg/dL than the group with lower blood lead levels (p < .05). Mean corpuscular volume and mean corpuscular hemoglobin were not significantly related to lead levels. Hemoglobin and hematocrit showed a non-significant positive correlation with blood lead, but the correlation between red blood cell count and blood lead levels was statistically significant (r = 0.185, p = .002). The findings suggest that a positive association between blood lead and some hematological indices may occur at relatively low blood lead concentration (mean < 5 μg/dL).
Accepted: 30 Mar 2014

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