Synthesis and characterization of poly(dimethylsiloxane)-poly(ethylene oxide)-heparin CBABC type block copolymers
DOI: 10.1163/156856289X00163
Title: Synthesis and characterization of poly(dimethylsiloxane)-poly(ethylene oxide)-heparin CBABC type block copolymers
Journal Title: Journal of Biomaterials Science, Polymer Edition
Volume: Volume 1
Issue: Issue 4
Publication Date: January 1989
Start Page: 299
End Page: 313
Published online: 2 Apr 2012
ISSN: 0920-5063
Affiliations:
a Department of Pharmaceutics, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA
b Department of Pharmaceutics, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA
c Department of Pharmaceutics, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA
d Department of Pharmaceutics, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA
e Department of Chemical Technology, University of Twente, Enschede, The Netherlands
f Department of Pharmaceutics, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA
Abstract: Heparin and poly(ethylene oxide) were coupled to a central anchoring block of poly(dimethylsiloxane) in order to investigate its blood compatible properties. Diamino telechelic poly(dimethylsiloxane) (PDMS-(NH2)2, Mw = 20000) was first modified to isocyanate functionalities using toluene 2,4-diisocyanate. This modified PDMS was then coupled to diamino-telechelic poly(ethylene oxide) (PEO-(NH2)2, Mw = 2000, 4000, 6000) to create BAB type copolymers having terminal free amino groups. These amino groups were covalently coupled to heparin containing terminal aldehyde groups using sodium cyanoborohydride to yield a bioactive, CBABC type block copolymer. The physical characterization of these copolymers was performed with IR, NMR, sulphur elemental analysis, Wilhelmy plate contact angle, and differential scanning calorimetry (DSC). CBABC block copolymer surfaces demonstrated heparin bioactivity in in vitro evaluation, and improved nonthrombogenic properties during ex vivo A-A shunt experiments.

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