The effects of aspartame on mast cells and basophils
DOI: 10.1016/0278-6915(86)90353-4
Title: The effects of aspartame on mast cells and basophils
Journal Title: Food and Chemical Toxicology
Volume: 24
Issue: 2
Publication Date: February 1986
Start Page: 171
End Page: 174
Published online: 21 November 2002
ISSN: 0278-6915
Author: E.F. Szucs
Affiliations: Mast Cell Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20205, USA
Abstract: ficial sweetener aspartame was studied to determine whether it had any direct effects on mast cells and basophils. Aspartame was not shown to be a direct mast cell or basophil secretagogue in vitro, or in vivo as assessed by skin testing. During an acute incubation, aspartame did not affect IgE-mediated histamine release from mast cells. However, mast cells cultured in aspartame for periods of up to 9 days showed enhanced rates of proliferation and decreased responsiveness to releasing stimuli. The effect of aspartame on proliferation of cells in culture could be ascribed to a non-specific enhancing effect of its constituent amino acids.

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