Short-Term Oral Toxicity Study of FAVOR PAC in Rats
DOI: 10.1006/rtph.2000.1449
Title: Short-Term Oral Toxicity Study of FAVOR PAC in Rats
Journal Title: Regulatory Toxicology and Pharmacology
Volume: 32
Issue: 3
Publication Date: December 2000
Start Page: 310
End Page: 316
Published online: online 12 March 2002
ISSN: 0273-2300
Affiliations:

  • a Stockhausen GmbH & Co KG, 47704, Krefeld, Germany

  • b ENVIRON International Corporation, 4350 N Fairfax Drive, Arlington, Virginia
  • Abstract: g>Short-Term rat feeding study was conducted to evaluate the oral toxicity of FAVOR PAC (CAS Registry No. 9003-04-7), one member of a family of cross-linked sodium polyacrylate polymers developed by Stockhausen GmbH & Co KG (Krefeld, Germany). FAVOR polymers are classified as superabsorbent polymers because of their ability to absorb and retain large volumes of fluid. In this Short-Term study, three groups of 10 male and 10 female Sprague–Dawley rats were administered 0 (control), 1, or 5% FAVOR PAC in the diet daily for up to 32 days. No significant changes in clinical signs, body weight and food consumption, functional observation battery results, ophthalmoscopy, hematology and clinical chemistries, or absolute and relative organ weights were observed. Significant differences between treated and control animals were limited to increases in water consumption and modifications in urinary ionic excretion. Both findings were likely the result of the relatively high concentration of sodium in the test article, and thus consistent with adaptive physiologic changes, not overt toxicity. In conclusion, levels of up to 5% FAVOR PAC in the diet produced no treatment-related toxicity in rats under the conditions of this Short-Term test (i.e., a NOAEL of 5% FAVOR PAC in the diet was identified).
    Received: 30 May 2000
    Keywords: CAS Registry No. 9003-04-7; FAVOR PAC; rat; sodium polyacrylate polymer; superabsorbent polymers; oral toxicity

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