Does properdin crosslink the cellular and the humoral immune response?
DOI: 10.1016/S0167-5699(98)01376-0
Title: Does properdin crosslink the cellular and the humoral immune response?
Journal Title: Immunology Today
Volume: 20
Issue: 1
Publication Date: 1 January 1999
Start Page: 17
End Page: 21
Published online: online 30 June 1999
ISSN: 1471-4906
Author: Wilhelm J Schwaeblea, Kenneth B.M Reidb
Affiliations:

  • a Dept of Microbiology and Immunology, University of Leicester, Leicester, UK LE1 9HN

  • b MRC Immunochemistry Unit, Dept of Biochemistry, University of Oxford, Oxford, UK OX1 3QU
  • Abstract: n, the only known positive regulator of complement activation, is produced by cells of the monocyte–macrophage, T-cell and granulocyte lineages. Complement activation products have an established role in the cellular immune response. However, here, Wilhelm Schwaeble and Kenneth Reid discuss current data demonstrating that leukocytes form a positive feedback loop of activation by properdin release.
    Email: ws5@leicester.ac.uk kbmreid@bioch.ox.ac.uk

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