Oral health status in children with acute lymphoblastic leukemia
DOI: 10.1016/j.critrevonc.2011.11.003
Title: Oral health status in children with acute lymphoblastic leukemia
Journal Title: Critical Reviews in Oncology/Hematology
Volume: 83
Issue: 3
Publication Date: September 2012
Start Page: 303
End Page: 309
Published online: online 2 December 2011
ISSN: 1040-8428
Author: Fawad JavedaAuthor Vitae, Achint Utrejab, Fernanda O. Bello Correac, Mansour Al-Askarae, Malik Hudieba, Faisal Qayyumd, Abdulaziz Al-Rasheedae, Khalid Almasf, Khalid Al-Hezaimiae
Affiliations:

  • a Eng. A.B. Research Chair for Growth Factors and Bone Regeneration, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh, Saudi Arabia

  • b Department of Craniofacial Sciences, Division of Orthodontics, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA

  • c Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Brazil

  • d Prosthodontics, Section of Dentistry, The Aga Khan University Hospital, Karachi, Pakistan

  • e Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia

  • f Division of Periodontology, University of Connecticut, Farmington, CT, USA
  • Abstract: is a malignancy of the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and accounts for nearly 75% of all newly diagnosed leukemias and 25% of all malignancies in childhood. The aim of the present study was to review the Oral health status in children with ALL. Databases were explored using various combinations of the following keywords: “acute lymphoblastic leukemia”, “children”, “inflammation”, “pediatric”, “periodontal disease” and “periodontitis”. Oral inflammatory conditions including chelitis, gingivitis, herpetic gingivostomatitis, mucositis, Oral candidiasis, periodontitis and ulcerations are common manifestations in children with ALL.ResultsPeriodontal inflammatory conditions and Oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations.ConclusionOral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.
    Accepted: 9 November 2011
    Keywords: Acute lymphoblastic leukemia; Children; Dental; Pediatric; Oral, and periodontal disease
    Result: Periodontal inflammatory conditions and oral mucositis were reported to be significantly higher in children with ALL as compared to healthy controls. Tooth morphological disorders including agenesis, microdontia, short roots and developmental defects in the enamel and dentin were more often observed in children with ALL as compared to healthy controls. Children with ALL have a reduced salivary flow rate, which makes them more susceptible to dental caries as compared to healthy children. Malocclusion due to microdontia may also trigger temporomandibular joint disorders in children with ALL; however, this relationship needs further investigations.ConclusionOral inflammatory conditions including mucositis and gingivitis are common in children with ALL as compared to healthy children. Tooth morphological disorders including microdontia and enamel and dentin are common manifestations in children with ALL.
    Email: fawjav@gmail.com

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