Clopidogrel Use in Children
DOI: 10.1016/j.jpeds.2005.05.006
Title: Clopidogrel Use in Children
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 657
End Page: 661
Published online: online 13 November 2005
ISSN: 0022-3476
Author: Yaron Finkelstein, MD, Laila Nurmohamed, BSc, Marina Avner, MD, Lee N. Benson, MD, FRCP(C), FACC, Gideon Koren, MD, FACMT, FRCPC
  • From the Department of Pediatrics, Divisions of Clinical Pharmacology and Toxicology and Cardiology, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada and Schneider Children's Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Accepted: 4 May 2005
    Received: 18 August 2004
    Revised: 17 March 2005
    Keywords: ADP, Adenosine diphosphate
    Conclusions: Clopidogrel was well tolerated. We suggest a starting dose of 1 mg/kg/day for children.
    Result: Fifteen infants and children with congenital and acquired heart disease were treated with clopidogrel (median age, 3.5 years; range, 6 weeks to 16 years). Dosages ranged from 1 to 6 mg/kg/day for periods between 1 month and 6 months. Although no thrombotic events were reported, 1 child had a bleeding complication (gastrointestinal) while on triple antithrombotic therapy. Other complications reported in adults, including rash and clinical thrombocytopenia, were not noted in this pediatric series.ConclusionsClopidogrel was well tolerated. We suggest a starting dose of 1 mg/kg/day for children.

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