Cognitive Functioning in Children with Early Onset Type 1 Diabetes and Severe Hypoglycemia
DOI: 10.1016/j.jpeds.2005.06.010
Title: Cognitive Functioning in Children with Early Onset Type 1 Diabetes and Severe Hypoglycemia
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 680
End Page: 685
Published online: online 13 November 2005
ISSN: 0022-3476
Author: Susan K. Strudwick, MPsych, Christy Carne, RN, John Gardiner, MP App Psych, Jonathan K. Foster, DPhil, Elizabeth A. Davis, FRACP, Timothy W. Jones, MD, FRACP
Affiliations:
  • From the Departments of Psychological Medicine and Diabetes & Endocrinology, Princess Margaret Hospital, Perth, and the Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia
  • Accepted: 3 June 2005
    Received: 30 December 2004
    Revised: 25 March 2005
    Keywords: CBCL, Achenbach Child Behavior Checklist: 4 - 18 years; CDI-S, Children's Depression Inventory–Short Form; CMS, Children's Memory Scale; SH, Severe hypoglycemia; T1DM, Type 1 diabetes; WISC-III, Wechsler Intelligence Scale for Children–Third Edition
    Conclusions: There was no clear evidence from this cohort that episodes of seizure or coma, even those occurring in very early childhood, resulted in broad cognitive dysfunction, nor was there evidence of specific memory difficulties at the time of testing in children and adolescents with early-onset T1DM.
    Result: No significant group differences were revealed on the intellectual, memory, or behavioral measures. Similarly, those participants with a history of early first seizure did not differ from their peers with no seizures. There were no significant group differences on the memory subtests that were examined given their potential sensitivity to compromised hippocampal function.ConclusionsThere was no clear evidence from this cohort that episodes of seizure or coma, even those occurring in very early childhood, resulted in broad cognitive dysfunction, nor was there evidence of specific memory difficulties at the time of testing in children and adolescents with early-onset T1DM.
    Email: Tim.Jones@health.wa.gov.au

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