Prenatal Impairment of Brain Serotonergic Transmission in Infants
DOI: 10.1016/j.jpeds.2005.06.025
Title: Prenatal Impairment of Brain Serotonergic Transmission in Infants
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 592
End Page: 596
Published online: online 13 November 2005
ISSN: 0022-3476
Author: Gabriel Manjarrez, MD, PhD, Ignacia Cisneros, MD, Rocio Herrera, MD, MSc, Felipe Vazquez, MD, MSc, Alejandro Robles, Jorge Hernandez, MD, PhD
Affiliations:
  • From the Laboratory of Developmental Neurochemistry, Specialties Hospital and Department of Biomedical Engineering, XXI Century National Medical Center and Service of Neonatology, Gynecology-Obstetrics Hospital “4”, Mexican Institute of Social Security, Mexico City, Mexico and Laboratory of Neurontogeny, Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies, Mexico City, Mexico
  • Accepted: 13 June 2005
    Received: 13 September 2004
    Revised: 11 May 2005
    Keywords: ACD, Citric acid, sodium citrate, dextrose; AEP, Auditory evoked potentials; AgCl, Silver/silver chloride; C, Control group; Cz, Vertex; EEG, Electroencephalogram; FGR, Fetal growth ratio; GABA, γ-amino butyric acid; IUGR, Intrauterine growth restriction; L-Trp, L-tryptophan; MS, Sum of squares minu
    Conclusions: In newborns with IUGR, the changes in measured plasma free fraction of L-Trp and in the amplitude the N1/P2 component of the AEP suggest an inverse association between free L-Trp and components of the AEP. The changes observed in the free fraction of L-Trp and AEP may be causally associated with brain serotonergic activity in utero. In IUGR, epigenetic factors such as stress-induced disturbances in brain serotonin metabolism or serotonergic activity, identifiable by alterations in AEP, influence cerebral sensory cortex development and may be causally associated with serotonin-related disorders in adulthood.
    Result: Plasma free L-Trp was increased and the amplitude of N1/P2 component was significantly decreased in IUGR relative to control infants. The free fraction of L-Trp and N1/P2 component had a negative association.ConclusionsIn newborns with IUGR, the changes in measured plasma free fraction of L-Trp and in the amplitude the N1/P2 component of the AEP suggest an inverse association between free L-Trp and components of the AEP. The changes observed in the free fraction of L-Trp and AEP may be causally associated with brain serotonergic activity in utero. In IUGR, epigenetic factors such as stress-induced disturbances in brain serotonin metabolism or serotonergic activity, identifiable by alterations in AEP, influence cerebral sensory cortex development and may be causally associated with serotonin-related disorders in adulthood.
    Email: willisga@df1.telmex.net.mx

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