Neonatal Outcome in Twin-To-Twin Transfusion Syndrome Treated with Fetoscopic Laser Occlusion of Vascular Anastomoses
DOI: 10.1016/j.jpeds.2005.06.004
Title: Neonatal Outcome in Twin-To-Twin Transfusion Syndrome Treated with Fetoscopic Laser Occlusion of Vascular Anastomoses
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 597
End Page: 602
Published online: online 13 November 2005
ISSN: 0022-3476
Affiliations:
  • From the Division of Neonatology, Department of Pediatrics, the Division of Fetal Medicine, and the Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
  • Accepted: 2 June 2005
    Received: 10 March 2005
    Revised: 12 May 2005
    Keywords: IVH, Intraventricular hemorrhage; TTTS, Chronic twin-to-twin transfusion syndrome
    Conclusions: Although perinatal outcome in TTTS has improved after laser therapy, neonatal mortality and morbidity rates remain high. Relative risk for adverse neonatal outcome is increased 2-fold in TTTS treated with laser relative to monochorionic twins without TTTS.
    Result: The neonatal mortality rate in the TTTS and no-TTTS group was 8% (6/76) and 3% (3/90), respectively. The rate of severe cerebral lesions on ultrasound scanning in the TTTS and no-TTTS group was 14% (10/72) and 6% (5/82), respectively. The incidence of adverse neonatal outcome (neonatal death, major neonatal morbidity, or severe cerebral lesions) in the TTTS and no-TTTS group was, respectively, 26% (20/76) and 13% (12/90) (RR = 1.97, 95% CI = 1.03 to 3.77).ConclusionsAlthough perinatal outcome in TTTS has improved after laser therapy, neonatal mortality and morbidity rates remain high. Relative risk for adverse neonatal outcome is increased 2-fold in TTTS treated with laser relative to monochorionic twins without TTTS.
    Email: e.lopriore@lumc.nl

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