Early Brain Injury in Premature Newborns Detected with Magnetic Resonance Imaging is Associated with Adverse Early Neurodevelopmental Outcome
DOI: 10.1016/j.jpeds.2005.06.033
Title: Early Brain Injury in Premature Newborns Detected with Magnetic Resonance Imaging is Associated with Adverse Early Neurodevelopmental Outcome
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 609
End Page: 616
Published online: online 13 November 2005
ISSN: 0022-3476
Author: Steven P. Miller, MD, Donna M. Ferriero, MD, Carol Leonard, PhD, Robert Piecuch, MD, David V. Glidden, PhD, J. Colin Partridge, MD, Marta Perez, BA, Pratik Mukherjee, MD, PhD, Daniel B. Vigneron, PhD, A. James Barkovich, MD
Affiliations:
  • From the Departments of Neurology, Pediatrics, Epidemiology and Biostatistics, and Radiology, University of California San Francisco, San Francisco, California
  • Accepted: 3 June 2005
    Received: 31 January 2005
    Revised: 1 April 2005
    Conclusions: In premature newborns, brain abnormalities are common on MRI early in life and are associated with adverse neurodevelopmental outcome.
    Result: Of 86 neonatal survivors, outcome was normal in 51 (59%), borderline in 22 (26%), and abnormal in 13 (15%). Moderate/severe MRI abnormalities were common on the first (37%) and second (32%) scans. Abnormal outcome was associated with increasing severity of white matter injury, ventriculomegaly, and intraventricular hemorrhage on MRI, as well as moderate/severe abnormalities on the first (relative risk [RR] = 5.6; P = .002) and second MRI studies (RR = 5.3; P = .03). Neuromotor abnormalities on neurologic examination near term age (RR = 6.5; P = .04) and postnatal infection (RR = 4.0; P = .01) also increased the risk for abnormal neurodevelopmental outcome.ConclusionsIn premature newborns, brain abnormalities are common on MRI early in life and are associated with adverse neurodevelopmental outcome.
    Email: jim.barkovich@radiology.ucsf.edu

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