Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?
DOI: 10.1016/j.jpeds.2005.06.005
Title: Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?
Journal Title: The Journal of Pediatrics
Volume: 147
Issue: 5
Publication Date: November 2005
Start Page: 617
End Page: 621
Published online: online 13 November 2005
ISSN: 0022-3476
Author: Manfred Modl, MD, Ernst Eber, MD, Doris Malle-Scheid, MD, Elisabeth Weinhandl, RT, Maximilian S. Zach, MD
Affiliations:
  • From the Respiratory and Allergic Disease Division, Paediatric Department, Medical University of Graz, Austria
  • Accepted: 2 June 2005
    Received: 18 October 2004
    Revised: 5 May 2005
    Keywords: CV, Coefficient of variation; ETRTC, End-tidal rapid thoracoabdominal compression; FEV0.5, Forced expiratory volume at 0.5 seconds after chest compression; FEV0.75, Forced expiratory volume at 0.75 seconds after chest compression; FEV1.0, Forced expiratory volume at 1.0 second after chest compressio
    Conclusions: The results of the current study indicate that bronchodilator responsiveness in infants with bronchiolitis is not age-dependent.
    Result: For the group, postbronchodilator values did not differ significantly from baseline (ΔFEV0.5, 3.8% ± 9.3%; ΔFEV0.75, 3.5% ± 9.5%; and ΔFEV1.0, 4.0 ± 9.8%). Eleven subjects showed significantly increased timed volumes; 3 presented with a decreased lung function; the remaining patients failed to show a significant change. The mean age of subjects with improved lung function did not differ significantly from the mean age of those with no or paradoxical responses (9.7 ± 4.7 vs 8.1 ± 4.1 months); there was no correlation of age with the size of the bronchodilator response.ConclusionsThe results of the current study indicate that bronchodilator responsiveness in infants with bronchiolitis is not age-dependent.

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