Mesoporous systems for poorly soluble drugs
DOI: 10.1016/j.ijpharm.2012.09.008
Title: Mesoporous systems for poorly soluble drugs
Journal Title: International Journal of Pharmaceutics
Volume: 453
Issue: 1
Publication Date: 30 August 2013
Start Page: 181
End Page: 197
Published online: online 7 September 2012
ISSN: 0378-5173
Affiliations:
  • Department of Applied Physics, University of Eastern Finland, POB 1627, FI-70211 Kuopio, Finland
  • Abstract: ion of inorganic Mesoporous materials in formulations of poorly water-soluble drugs to enhance their dissolution and permeation behavior is a rapidly growing area in pharmaceutical materials research. The benefits of Mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation, and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. The main concern regarding their clinical applications is still the safety aspect even though most of them have been reported to be safely excreted, and a rather extensive toxicity screening has already been conducted with the most frequently studied Mesoporous materials. In addition, the production of the materials on a large scale and at a reasonable cost may be a challenge when considering the utilization of the materials in industrial processes. However, if Mesoporous materials could be employed in the industrial crystallization processes to produce hybrid materials with poorly soluble compounds, and hence to enhance their oral bioavailability, this might open new avenues for the pharmaceutical industry to employ nanotechnology in their processes.
    Accepted: 3 September 2012
    Received: 11 May 2012
    Revised: 31 August 2012
    Keywords: Mesoporous inorganic materials; Drug delivery; Enhanced dissolution; Bioavailability
    Tel: +358 403552470.Copyright ©
    Email: pekka.lehto@uef.fi

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