Effectiveness of dietary 25‐ and 1‐hydroxycholecalciferol in combating tibial dyschondroplasia in broiler chickens
DOI: 10.1080/00071669608417872
Title: Effectiveness of dietary 25‐ and 1‐hydroxycholecalciferol in combating tibial dyschondroplasia in broiler chickens
Journal Title: British Poultry Science
Volume: Volume 37
Issue: Issue 2
Publication Date: May 1996
Start Page: 413
End Page: 421
Published online: 8 Nov 2007
ISSN: 0007-1668
Affiliations:
a Roslin Institute , Roslin, Midlothian, EH25 9PS, Scotland
Abstract: 1. Three experiments were carried out to determine the effects of feeding diets containing different concentrations of cholecalciferol, 1 a‐hydroxychole‐calciferol (1‐HCC), 25‐hydroxycholecalciferol (25‐HCC), 1,25‐dihydroxycholecalcif‐erol (1,25‐DHCC) and ascorbic acid on the incidences and severities of tibial dyschondroplasia (TD) at 3 weeks of age in male broiler chicks.2. In experiment 1, replacing 75 μg cholecalciferol/kg with the same weight of 25‐HCC decreased significantly (P<0.01) the incidence of TD from 65 to 10%.3. In experiment 2, the incidence of TD in the control group was lower, but feeding amounts of 25‐HCC up to 250 μg/kg had a linear effect on the incidence of TD that was significant at P=0.06. There was no effect or interactions with dietary addition of 250 mg ascorbic acid/kg. dietary addition of 5 μg 1‐HCC/kg decreased TD incidence from 21 to 5%, though the effect was not significant (P>0.1). 4. TD incidence in experiment 3 was too low to determine an effect of 25‐HCC or 1,25‐DHCC on TD incidence, though in this, as in both other experiments, the severities of TD lesions were always lower with diets containing cholecalciferol metabolites.5. Hypercalcaemia was not observed after feeding up to 250 μg 25‐HCC/kg in either experiments 2 or 3.6. It is concluded that 25‐HCC may be an effective practical means of improving broiler leg health by alleviating the incidence and severity of TD.
Accepted: 20 Nov 1995

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